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Related Experiment Video

Updated: Jun 26, 2026

A Method for Evaluating the Reinforcing Properties of Ethanol in Rats without Water Deprivation, Saccharin Fading or Extended Access Training

A Method for Evaluating the Reinforcing Properties of Ethanol in Rats without Water Deprivation, Saccharin Fading or Extended Access Training

Published on: January 29, 2017

Ethanol-induced conditioned taste avoidance: reward or aversion?

Chuang Liu¹, John Showalter, Patricia Sue Grigson

¹Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA. chliu@psu.edu

Alcoholism, Clinical and Experimental Research

|January 6, 2009

Summary

Ethanol

Area of Science:

Neuroscience
Behavioral Neuroscience
Pharmacology

Background:

Rats avoid tastes paired with drugs, anticipating rewarding effects.
Ethanol's role in taste aversion is unclear, unlike morphine or cocaine.
This study investigates ethanol's rewarding vs. aversive properties in taste aversion.

Purpose of the Study:

To determine if ethanol-induced taste aversion is exaggerated in drug-sensitive Lewis rats.
To investigate if gustatory thalamus lesions prevent ethanol's taste aversion effects.

Main Methods:

Lewis and Fischer rats were conditioned with saccharin and ethanol injections.
Gustatory thalamus lesions were performed in Sprague-Dawley rats.
Taste aversion was assessed after repeated ethanol-saccharin pairings.

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A Simple Way to Measure Alterations in Reward-seeking Behavior Using Drosophila melanogaster

Published on: December 15, 2016

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Last Updated: Jun 26, 2026

A Method for Evaluating the Reinforcing Properties of Ethanol in Rats without Water Deprivation, Saccharin Fading or Extended Access Training

A Method for Evaluating the Reinforcing Properties of Ethanol in Rats without Water Deprivation, Saccharin Fading or Extended Access Training

Published on: January 29, 2017

A Procedure to Observe Context-induced Renewal of Pavlovian-conditioned Alcohol-seeking Behavior in Rats

A Procedure to Observe Context-induced Renewal of Pavlovian-conditioned Alcohol-seeking Behavior in Rats

Published on: September 19, 2014

A Simple Way to Measure Alterations in Reward-seeking Behavior Using Drosophila melanogaster

A Simple Way to Measure Alterations in Reward-seeking Behavior Using Drosophila melanogaster

Published on: December 15, 2016

Main Results:

Ethanol did not cause greater taste aversion in Lewis rats compared to Fischer rats.
Gustatory thalamus lesions blocked aversion to low-dose ethanol (0.75 g/kg).
Lesions did not affect aversion to high-dose ethanol (1.5 g/kg).

Conclusions:

Ethanol's taste aversion effects depend on dose.
Both rewarding and aversive properties of ethanol contribute to taste aversion.