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Updated: Jun 26, 2026

Continuous Theta Burst Stimulation of the Posterior Medial Frontal Cortex to Experimentally Reduce Ideological Threat Responses
06:42

Continuous Theta Burst Stimulation of the Posterior Medial Frontal Cortex to Experimentally Reduce Ideological Threat Responses

Published on: September 28, 2018

Prefrontal and midline interactions mediating behavioural control.

Catherine Fassbender1, Robert Hester, Kevin Murphy

  • 1School of Psychology and Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland.

The European Journal of Neuroscience
|January 6, 2009
PubMed
Summary
This summary is machine-generated.

Cognitive control involves interactions between frontal and midline brain regions. This study shows that increased top-down control, indicated by left dorsolateral prefrontal activation, reduces conflict processing in the pre-supplementary motor area.

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Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication
09:26

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Published on: February 6, 2019

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Cognitive Control Research

Background:

  • Top-down control processes are crucial for behavior, interacting with stimulus-driven demands.
  • Frontal and midline brain regions are implicated in cognitive control, but their specific roles and interactions require further investigation.

Purpose of the Study:

  • To investigate the interplay between top-down control and response conflict.
  • To examine how cue-induced top-down control modulates neural activity during inhibitory control tasks.

Main Methods:

  • Functional magnetic resonance imaging (fMRI) was employed.
  • A GO/NO-GO task with cued and uncued inhibitory events was utilized.
  • Within-subject, trial-by-trial analysis examined neural activation patterns.

Main Results:

  • Higher left dorsolateral prefrontal activation (indicating top-down control) preceded NO-GO trials.
  • This increased top-down control was associated with reduced activation in the pre-supplementary motor area during NO-GO trials.
  • Significant trial-by-trial interactions between lateral and midline brain regions were observed.

Conclusions:

  • Prefrontal and midline brain regions collaborate to implement cognitive control.
  • Individual differences in top-down control strategies are reflected in the dynamic interactions between these brain areas.