Expression of genes encoding kinin receptors in peripheral blood mononuclear cells from patients with acute coronary

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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

J Dabek1, A Kulach, G Smolka

  • 1Department of Cardiology, Medical University of Silesia, Katowice, Poland.

Internal Medicine Journal
|January 6, 2009
PubMed

Insights

Patients with acute coronary syndrome (ACS) exhibit an altered B1 receptor/B2 receptor ratio, suggesting a role for kinin signaling in the disease process. This imbalance may indicate increased activation of immune cells involved in atherosclerosis.

Area of Science:

  • Cardiovascular Biology
  • Molecular Medicine
  • Immunology

Background:

  • Inflammation is central to atherosclerosis, from plaque development to rupture causing acute coronary syndromes (ACS) like unstable angina (UA) and myocardial infarction (MI).
  • Kinins, peptides mediating inflammation and vasodilation, act via B1 and B2 receptors, but their specific role in ACS remains unclear.

Purpose of the Study:

  • To investigate the gene expression of B1 and B2 kinin receptors in patients diagnosed with ACS.
  • To determine if kinin receptor expression patterns differ between ACS patients and healthy individuals.

Main Methods:

  • Quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) was used to measure mRNA levels.
  • Total mRNA was extracted from peripheral blood mononuclear cells of 40 ACS patients and 10 healthy controls.
  • The ratio of B1 receptor (B1R) to B2 receptor (B2R) mRNA was calculated and compared between groups.

Main Results:

  • ACS patients displayed an inverted B1R/B2R ratio compared to healthy controls (P < 0.01 for MI vs C; P < 0.05 for UA vs C).
  • A significant decrease in B2R mRNA levels was observed in the MI group compared to controls (P < 0.05).
  • No significant differences in B1R expression were found between MI and control groups, nor were differences observed in B1R or B2R expression between UA and control groups.

Conclusions:

  • Patients with ACS present with an altered B1R/B2R ratio, indicating a potential disruption in kinin signaling pathways.
  • This disturbed kinin signaling may be linked to heightened activation of circulating mononuclear cells, which are key players in atherosclerotic plaque progression and rupture.
Abstract

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