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Thinned-skull Cortical Window Technique for In Vivo Optical Coherence Tomography Imaging

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Published on: November 19, 2012

Optical coherence tomography (OCT) reveals depth-resolved dynamics during functional brain activation.

Yu Chen¹, Aaron D Aguirre, Lana Ruvinskaya

¹Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Journal of Neuroscience Methods

|January 6, 2009

Summary

Optical coherence tomography (OCT) offers depth-resolved brain imaging, complementing optical intrinsic signal imaging (OISI). This new technology reveals layer-specific functional brain activation dynamics, advancing neuroimaging capabilities.

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Cerebral Blood Flow-Based Resting State Functional Connectivity of the Human Brain using Optical Diffuse Correlation Spectroscopy

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Published on: May 27, 2020

Area of Science:

Neuroscience
Biomedical Engineering
Optical Imaging

Background:

Optical intrinsic signal imaging (OISI) maps brain activity in 2D.
Optical coherence tomography (OCT) provides depth-resolved functional brain imaging.

Purpose of the Study:

To evaluate co-registered OCT and OISI for simultaneous functional brain imaging.
To assess OCT's capability in providing depth-resolved activation dynamics.

Main Methods:

Simultaneous co-registered OCT and OISI performed on rat somatosensory cortex.
Forepaw electrical stimulation used as a functional stimulus.
Analysis of fractional signal change measurements from OCT.

Main Results:

OCT functional signals correlated well with OISI hemodynamic signals.
OCT provided depth-resolved, layer-specific dynamics of functional activation.
Evidence of retrograde vessel dilation observed through OCT.

Conclusions:

Co-registered OCT and OISI provide complementary functional neuroimaging data.
OCT is a promising technology for detailed, layer-specific brain activity mapping.
OCT enhances understanding of functional hemodynamics in the brain.