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Two patients with bepridil-induced interstitial pneumonia
Masataka Watanabe1, Yoshifumi Takata, Shinya Fukasawa
1Department of Cardiology, Tokyo Medical University, 6-7-1 Nishi-Shinjuku, Shinjuku-ku, Tokyo, Japan. watamasa@tokyo-med.ac.jp
Summary
Bepridil can cause interstitial pneumonia, a rare but serious adverse reaction. Healthcare providers should monitor patients for respiratory symptoms like dyspnea during bepridil treatment.
Area of Science:
- Cardiology
- Pulmonology
- Pharmacology
Background:
- Arrhythmia treatment often involves medications with potential side effects.
- Bepridil is an antiarrhythmic drug used for managing conditions like atrial fibrillation.
Observation:
- Two male patients, aged 69 and 72, developed interstitial pneumonia during bepridil therapy for arrhythmias.
- Symptoms of dyspnea appeared on the 20th and 60th days of treatment, respectively.
Findings:
- Diagnosis of interstitial pneumonia was confirmed through physical examination and imaging.
- One patient recovered with steroid pulse therapy; the other improved after bepridil discontinuation.
Implications:
- Bepridil-induced interstitial pneumonia is a critical adverse drug reaction to recognize.
- Clinicians must consider this diagnosis in patients presenting with new-onset dyspnea while on bepridil.
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