Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Acute Pancreatitis II: Pathophysiology01:21

Acute Pancreatitis II: Pathophysiology

The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute Pancreatitis I: Introduction01:25

Acute Pancreatitis I: Introduction

Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Acute kidney injury markers in pediatric pancreatitis: Differentiating disease states and assessing severity.

Journal of pediatric gastroenterology and nutrition·2025
Same author

AXL and MERTK facilitate tissue repair in severe acute pancreatitis via a CCR5-dependent neutrophil and macrophage crosstalk.

Cell communication and signaling : CCS·2025
Same author

Visceral pain-related acute actions of cerulein on mouse and human sensory neurons.

Molecular pain·2025
Same author

Renalase peptides reduce pancreatitis severity in mice.

American journal of physiology. Gastrointestinal and liver physiology·2024
Same author

Acute pancreatitis: pathogenesis and emerging therapies.

Journal of pancreatology·2024
Same author

The Risk of Colonic Strictures with Colitis Following Hemolytic Uremic Syndrome: A Case Report of a Toddler.

JPGN reports·2023

Related Experiment Video

Updated: Jun 26, 2026

A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice
14:39

A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice

Published on: January 9, 2026

Molecular basis for pancreatitis.

Edwin Thrower1, Sohail Husain, Fred Gorelick

  • 1Department of Internal Medicine, Section of Digestive Diseases, Yale University School of Medicine, New Haven, CT, USA.

Current Opinion in Gastroenterology
|January 6, 2009
PubMed
Summary

Recent advances in pancreatitis research reveal new protective mechanisms and genetic factors. Understanding these molecular insights, including protease activated receptor 2 and toll-like receptor 4, is key for developing novel pancreatitis therapies.

More Related Videos

A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion
06:44

A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion

Published on: February 28, 2021

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
07:38

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection

Published on: May 10, 2024

Related Experiment Videos

Last Updated: Jun 26, 2026

A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice
14:39

A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice

Published on: January 9, 2026

A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion
06:44

A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion

Published on: February 28, 2021

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
07:38

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection

Published on: May 10, 2024

Area of Science:

  • Molecular mechanisms of pancreatic diseases
  • Translational research in gastroenterology

Background:

  • Acute and chronic pancreatitis represent significant clinical challenges.
  • Understanding the molecular underpinnings is crucial for therapeutic development.

Purpose of the Study:

  • To review recent clinical and basic science studies on acute and chronic pancreatitis.
  • To highlight advancements in understanding molecular mechanisms over the past year.

Main Methods:

  • Review of recent literature on acute and chronic pancreatitis.
  • Focus on molecular mechanisms, genetic factors, and animal models.

Main Results:

  • Development of advanced animal models for severe acute and chronic pancreatitis.
  • Identification of protective roles for protease activated receptor 2 and heat shock protein 70.
  • Genetic polymorphisms in toll-like receptor 4 may influence infection risk in acute pancreatitis.
  • Transient receptor potential vanilloid subtype 1 mediates pain in chronic pancreatitis models.
  • Chymotrypsin C's role in degrading trypsin and its link to chronic pancreatitis susceptibility, particularly with alcohol abuse.

Conclusions:

  • Improved animal models are essential for future therapeutic studies.
  • Genetic insights and pain response mechanisms offer potential therapeutic targets.
  • Further research into molecular pathways will guide treatment strategies for both acute and chronic pancreatitis.