Defocus sensitivity optimization using the defocus Taylor expansion of the optical transfer function
Related Experiment Video
Updated: Jun 26, 2026

Direct Force Measurements of Subcellular Mechanics in Confinement using Optical Tweezers
Published on: August 31, 2021
1Rocky Mound Engineering, 116 White Pine Court, Macon, Georgia 31216, USA. dsbarwick@cox.net
Abstract:
The Taylor expansion of the incoherent optical transfer function with respect to defocus is a valuable tool in the design and analysis of computational imaging systems. It efficiently describes the behavior of the system near best focus and beyond. Formulas for computing the coefficients in this expansion are derived and shown to be amenable to efficient digital calculation. Their application to the design of phase masks for systems insensitive to defocus aberrations and for systems that estimate object range are explored.
Related Concept Videos
Focusing of Light in the Eye
Taylor Series
Imaging Biological Samples with Optical Microscopy
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...

