Related Experiment Video
Updated: Jun 26, 2026

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach
Published on: July 3, 2020
A Note on Conditional AIC for Linear Mixed-Effects Models
Hua Liang1, Hulin Wu, Guohua Zou
1Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, New York 14642, U.S.A. hliang@bst.rochester.edu.
Abstract:
The conventional model selection criterion AIC has been applied to choose candidate models in mixed-effects models by the consideration of marginal likelihood. Vaida and Blanchard (2005) demonstrated that such a marginal AIC and its small sample correction are inappropriate when the research focus is on clusters. Correspondingly, these authors suggested to use conditional AIC. The conditional AIC is derived under the assumptions of the variance-covariance matrix or scaled variance-covariance matrix of random effects being known. We develop a general conditional AIC but without these strong assumptions. This allows Vaida and Blanchard's conditional AIC to be applied in a wide range. Simulation studies show that the proposed method is promising.
Related Concept Videos
Assumptions of Survival Analysis
Introduction To Survival Analysis
The primary goal of survival analysis is to estimate survival time—the time until a...
Friedman Two-way Analysis of Variance by Ranks
Truncation in Survival Analysis
Left truncation occurs when individuals who experienced the event of interest before a certain time are not included in the study. This is often due to a "delayed entry" into the study where only those who survive until a certain entry point are observed.
Comparing the Survival Analysis of Two or More Groups
Parameters Affecting Nonlinear Elimination: Zero-Order Input, First-Order Absorption and Two-Compartment Model
When a drug is administered through a constant intravenous infusion and eliminated via nonlinear pharmacokinetics, it follows zero-order input. For example, oral drugs undergo first-order absorption upon administration and are eliminated through nonlinear pharmacokinetics.
In the case of subcutaneously administered drugs,...