Related Experiment Video
Updated: Feb 16, 2026

Chromosome Replicating Timing Combined with Fluorescent In situ Hybridization
Published on: December 10, 2012
Models for chromosomal replication-independent non-B DNA structure-induced genetic instability
Guliang Wang1, Karen M Vasquez
1Department of Carcinogenesis, University of Texas M.D. Anderson Cancer Center, Science Park-Research Division, 1808 Park Road 1-C, Smithville, TX 78957, USA.
Abstract:
Regions of genomic DNA containing repetitive nucleotide sequences can adopt a number of different structures in addition to the canonical B-DNA form: many of these non-B DNA structures are causative factors in genetic instability and human disease. Although chromosomal DNA replication through such repetitive sequences has been considered a major cause of non-B form DNA structure-induced genetic instability, it is also observed in non-proliferative tissues. In this review, we discuss putative mechanisms responsible for the mutagenesis induced by non-B DNA structures in the absence of chromosomal DNA replication.
More Related Videos
Related Concept Videos
Spontaneous and Induced Mutations
The DNA Replication Fork
Homologous Recombination
DNA Replication
Replication in Prokaryotes
DNA replication...
Fixing Double-strand Breaks
Fixing Double-strand Breaks

