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Related Experiment Video

Updated: Jun 26, 2026

Rapid Fabrication of Custom Microfluidic Devices for Research and Educational Applications
05:33

Rapid Fabrication of Custom Microfluidic Devices for Research and Educational Applications

Published on: November 20, 2019

Fabrication of gravity-driven microfluidic device.

H Yamada1, Y Yoshida, N Terada

  • 1Graduate School of Engineering, Toyo University, 2100 Kujirai, Kawagoe, Saitama 350-8585, Japan. yamada@yitc.go.jp

The Review of Scientific Instruments
|January 7, 2009
PubMed
Summary
This summary is machine-generated.

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This study presents a novel microfluidic device for blood analysis. The system enables precise blood cell focusing and observation of red blood cell deformation, advancing micro total analysis systems.

Area of Science:

  • Biomedical Engineering
  • Microfluidics
  • Cellular Biology

Background:

  • Micro total analysis systems (MTAS) offer miniaturized platforms for complex biological assays.
  • Accurate manipulation and observation of blood cells are crucial for effective blood diagnostics.
  • Existing microfluidic devices face challenges in precise cell focusing and deformation analysis.

Purpose of the Study:

  • To develop and characterize a novel microfluidic device for blood analysis.
  • To enable precise focusing and alignment of blood cells within microchannels.
  • To facilitate the observation of red blood cell deformation using artificial capillary vessels.

Main Methods:

  • Fabrication of a microfluidic device using laser ablation on stacked thermosetting resin and fluororesin films.

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Fabricating High-viscosity Droplets using Microfluidic Capillary Device with Phase-inversion Co-flow Structure

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Fabrication of the Thermoplastic Microfluidic Channels
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Fabrication of the Thermoplastic Microfluidic Channels

Published on: February 3, 2008

Related Experiment Videos

Last Updated: Jun 26, 2026

Rapid Fabrication of Custom Microfluidic Devices for Research and Educational Applications
05:33

Rapid Fabrication of Custom Microfluidic Devices for Research and Educational Applications

Published on: November 20, 2019

Fabricating High-viscosity Droplets using Microfluidic Capillary Device with Phase-inversion Co-flow Structure
08:02

Fabricating High-viscosity Droplets using Microfluidic Capillary Device with Phase-inversion Co-flow Structure

Published on: April 17, 2018

Fabrication of the Thermoplastic Microfluidic Channels
16:00

Fabrication of the Thermoplastic Microfluidic Channels

Published on: February 3, 2008

  • Integration of a three-pronged microchannel (50-150 µm width, 45 µm depth) and artificial capillary vessels (5 µm diameter, 100 µm length).
  • Utilized gravity, sheath flow, and varied groove patterns for blood cell manipulation and focusing.

    • Main Results:

    • Successfully fabricated a 3D microfluidic device capable of transporting and focusing blood cells.
    • Demonstrated the ability of artificial capillary vessels to facilitate red blood cell deformation observation.
    • Observed red blood cell deformation under microscopic examination within the fabricated vessels.

    Conclusions:

    • The developed microfluidic device is effective for blood cell focusing and analysis.
    • The artificial capillary vessels provide a suitable environment for studying red blood cell mechanics.
    • This technology advances the capabilities of micro total analysis systems for hematological diagnostics.