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Updated: Jun 26, 2026

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding
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Structural insight into G-protein coupled receptor binding by apelin.

David N Langelaan1, E Meghan Bebbington, Tyler Reddy

  • 1Department of Biochemistry & Molecular Biology, Dalhousie University, Halifax, Nova Scotia B3H 1X5 Canada.

Biochemistry
|January 7, 2009
PubMed
Summary

Apelin peptides, ligands for APJ receptors, show increased structure at low temperatures. This structural change, particularly in key binding regions, suggests a temperature-dependent mechanism for apelin-APJ receptor interaction.

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