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Updated: Jun 26, 2026

Generation of Human CD40-activated B cells
Published on: October 16, 2009
Expression of CD320 in human B cells in addition to follicular dendritic cells
Whajung Cho1, Jinsuk Choi, Chan-Hum Park
1Department of Microbiology and Immunology, Kangwon National University College of Medicine, Chuncheon, Korea.
Abstract:
CD320 has been recently discovered and reported as a follicular dendritic cell (FDC) protein. Although CD320 is known to enhance proliferation of germinal center (GC) B cells, little other information is available. In this study, we investigated its cellular distribution in the GC. Confocal microscopy of human tonsil sections revealed co-localization of CD320 with CD19 and CD38 but not with CD3 indicating that GC B cells expressed CD320 in addition to FDC. In purified GC B cells, CD320 expression was inhibited in the nucleus, membrane and cytoplasm. Reverse transcriptase-polymerase chain reaction confirmed CD320 mRNA expression in B cells. These finding indicate that CD320 is expressed in B cells in addition to FDC, and that its GC activity may be more complicated than previously thought.
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