Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...

Bioavailability Enhancement: Drug Solubility Enhancement

Bioavailability Enhancement: Drug Solubility Enhancement

Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...

Bioavailability Enhancement: Drug Permeability Enhancement

Bioavailability Enhancement: Drug Permeability Enhancement

After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...

Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems

Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems

Bioavailability is a critical pharmacological concept that measures the extent and rate at which an active drug ingredient or therapeutic moiety enters the systemic circulation, remaining unchanged. It's a pivotal factor in determining a drug's efficacy and safety.The Biopharmaceutics Classification System (BCS) plays an essential role in drug development by categorizing drugs into four classes based on their solubility and permeability. This classification aids in understanding drug absorption...

Factors Influencing Drug Absorption: Drug Dissolution

Factors Influencing Drug Absorption: Drug Dissolution

The pharmacokinetic journey of drugs from solid oral dosage forms into systemic circulation is multifaceted. It begins with disintegration, a prerequisite ensuring a solid dosage form's subdivision into minute particles. Dissolution occurs next as these granulated entities solubilize in gastrointestinal fluids. This solubilization is crucial for the succeeding stage, permeation, which describes the traversal of the drug across the intestinal membrane and its subsequent entry into the blood...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Regeneration of the structure and function of estrogen-deficient vaginal epithelium by a novel phytoestrogen-related compound.

Menopause (New York, N.Y.)·2026

Same author

Comparative <i>In Vitro</i> Release Profiling of Brand and Generic Metoprolol Extended-Release Formulations in the Context of Product Switching.

Die Pharmazie·2026

Same author

Hydroxypropyl cellulose/thermoplastic polyurethane blend films with reversible optical performance triggered by water.

Carbohydrate polymers·2026

Same author

DksA inhibitors against intracellular and persistent <i>Salmonella</i> are effective in acute models of infection.

Science advances·2026

Same author

Colour of medicines and children's acceptability: What children think of the colour of oral dosage forms?

Frontiers in drug delivery·2026

Same author

Re-engineering chitin: From poor processability to functional hydrogels via ketone modification and dynamic crosslinking.

Carbohydrate polymers·2026

Search research articles

Related Experiment Video

Updated: Jun 26, 2026

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Published on: August 15, 2016

Improving glyburide solubility and dissolution by complexation with hydroxybutenyl-beta-cyclodextrin.

Sandra Klein¹, Michael F Wempe, Thomas Zoeller

¹Goethe University, Institute of Pharmaceutical Technology, Frankfurt/Main, Germany. sandra.klein@em.uni-frankfurt.de

The Journal of Pharmacy and Pharmacology

|January 8, 2009

Summary

This summary is machine-generated.

Hydroxybutenyl-beta-cyclodextrin (HBenBCD) significantly enhances glyburide solubility and dissolution rates. This complexation may improve the bioavailability of glyburide, a key type 2 diabetes medication.

More Related Videos

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

Published on: September 20, 2017

Related Experiment Videos

Last Updated: Jun 26, 2026

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Published on: August 15, 2016

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

Published on: September 20, 2017

Area of Science:

Pharmaceutical Sciences
Drug Delivery Systems

Background:

Glyburide, a vital medication for type 2 diabetes, suffers from poor aqueous solubility, limiting its bioavailability.
Developing strategies to enhance glyburide's solubility is crucial for improving therapeutic efficacy.

Purpose of the Study:

To investigate the complexation of glyburide with hydroxybutenyl-beta-cyclodextrin (HBenBCD).
To evaluate the impact of HBenBCD on glyburide's aqueous solubility and dissolution rate in vitro.

Main Methods:

Glyburide and its HBenBCD complex were tested in simulated gastrointestinal media (fasted and fed states).
Solubility and dissolution profiles were analyzed to assess drug performance.

Main Results:

HBenBCD complexation resulted in an approximately 400-fold increase in glyburide aqueous solubility at 14 wt% drug load.
Significant improvements in glyburide solubility were observed across all tested physiologically relevant media.
Dissolution experiments demonstrated markedly increased drug release rates and total drug amounts.

Conclusions:

Complexation with HBenBCD offers a promising approach to enhance glyburide's solubility and dissolution.
This strategy holds potential for improving the overall bioavailability of glyburide for type 2 diabetes treatment.