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Updated: Jun 26, 2026

ALS - Motor Neuron Disease: Mechanism and Development of New Therapies
Published on: July 29, 2007
Amyotrophic lateral sclerosis and neurosarcoidosis: a case report
I-Hweii Amy Chen1, Hiroshi Mitsumoto, Jean P Vonsattel
1Department of Neurology and the Eleanor and Lou Gehrig MDA/ALS Research Center, Columbia University, New York, New York, USA.
Abstract:
Amyotrophic lateral sclerosis (ALS) remains a clinical diagnosis without definable biomarkers. The pathomechanism of motor neuron degeneration in ALS has yet to be elucidated. Here we present a case of limb-onset ALS, with autopsy findings of Bunina bodies and skein-like inclusions, as well as sarcoid granulomas predominating among motor neurons. The targeting of the motor neurons by the sarcoid inflammation raises questions regarding the role of cellular immunity in the pathomechanisms for ALS.
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