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[Virus-induced autoimmunity phenomena in experimental animals (author's transl)]
Experimentelle Pathologie
|January 1, 1977
Summary
Herpes simplex virus infection can alter host cell immunogenicity, potentially disrupting self-recognition. Rabbits immunized with virus-infected testes cells developed antibodies against their own cells, indicating a breakdown in self-tolerance.
Area of Science:
- Immunology
- Virology
- Cell Biology
Context:
- Viral infections can alter host cell immunogenicity, potentially leading to autoimmune responses.
- Herpes simplex virus (HVH) types 1 and 2 are common human pathogens with known immunomodulatory effects.
Purpose:
- To investigate the immunogenicity of autologous testes cells infected with herpes simplex virus (HVH) types 1 and 2 in rabbits.
- To determine if immunization with virus-infected autologous cells can induce antibodies against self-antigens.
Summary:
- Rabbits were immunized with autologous testes cells infected with HVH types 1 or 2.
- Histological examination revealed globulin deposits in the testes of 14 out of 15 immunized rabbits.
- Antibodies against autologous testes cells were detected after immunization, suggesting a loss of self-tolerance.
Impact:
- This study provides evidence that viral infections can break self-tolerance, potentially contributing to autoimmune diseases.
- The findings highlight the importance of understanding virus-host interactions in the context of autoimmune disorders.