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Negative affect predicts subsequent cognitive change in multiple sclerosis.

Christopher Christodoulou1, Patricia Melville, William F Scherl

  • 1Department of Neurology, State University of New York at Stony Brook, Stony Brook, New York 11794-8121, USA. christopher.christodoulou@stonybrook.edu

Journal of the International Neuropsychological Society : JINS
|January 9, 2009
PubMed
Summary
This summary is machine-generated.

Negative affect, including depression and anxiety, predicts cognitive decline in multiple sclerosis (MS). Higher baseline negative affect in MS patients is linked to greater cognitive performance decreases over time.

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Area of Science:

  • Neuroscience
  • Psychology
  • Clinical Medicine

Background:

  • Cognitive impairment is a significant challenge for individuals with multiple sclerosis (MS).
  • Understanding predictors of cognitive change is crucial for managing MS progression.
  • Previous research has explored various factors, but the role of psychological state requires further investigation.

Purpose of the Study:

  • To identify baseline predictors of cognitive change in a cohort of individuals with multiple sclerosis (MS).
  • To examine the relationship between psychological factors, particularly negative affect, and longitudinal cognitive performance in MS.

Main Methods:

  • A longitudinal study involving 38 participants diagnosed with relapsing-remitting or secondary progressive MS.
  • Neuropsychological tests were administered at baseline and approximately 1 year later to assess cognitive function.
  • Self-report measures assessed depression, anxiety, fatigue, apathy, and positive/negative affect at baseline.

Main Results:

  • Baseline negative affect (depressed mood, state anxiety, negative affective state) significantly predicted cognitive decline over one year.
  • Higher levels of negative affect at baseline were associated with greater relative decreases in cognitive performance.
  • This predictive relationship was observed longitudinally, independent of cross-sectional cognition, and particularly impacted episodic memory.

Conclusions:

  • Negative affect is a key predictor of cognitive change in individuals with multiple sclerosis.
  • Interventions targeting negative psychological states may be important for preserving cognitive function in MS.
  • These findings highlight the unique predictive value of negative affect among assessed baseline measures.