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Inhibition of pathogen adhesion to host cells by polysaccharides from Panax ginseng
Ji-Hye Lee1, Jin Sun Shim, Mi-Sook Chung
1Department of Food Technology, School of Life Sciences and Biotechnology, Korea University.
Abstract:
PG-F2 and PG-HMW from Panax ginseng are pectin-type polysaccharides and PG-HMW might be an arabinogalactan. They demonstrated strong anti-adhesive activities against oral and skin pathogens to host cell lines in a dose-dependent manner from 0.1 to 2.0 mg/ml. While enzymatic hydrolysis caused complete loss of anti-adhesive activities, partial hydrolysis produced oligosaccharides with anti-adhesive properties. PG-F2 and PG-HMW might have a selective anti-adhesive effect against certain pathogenic bacteria without adverse effects on commensal bacteria.
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