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Congenital anomalies in diabetic pregnancy

Ulf J Eriksson1

  • 1Department of Medical Cell Biology, Uppsala University, Biomedical Center, PO Box 571, SE-75123 Uppsala, Sweden. ulf.eriksson@mcb.uu.se

Seminars in Fetal & Neonatal Medicine
|January 10, 2009
PubMed

Insights

Infants born to diabetic mothers have higher rates of congenital malformations. Research aims to understand the teratogenic process for prevention, with potential therapies including antioxidants and folic acid.

Area of Science:

  • Reproductive Medicine
  • Developmental Biology
  • Endocrinology

Background:

  • Congenital malformations occur more frequently in infants of diabetic women compared to non-diabetic women.
  • Understanding the causes and prevention of these malformations is crucial for improving pregnancy outcomes.

Purpose of the Study:

  • To elucidate the teratogenic process underlying diabetes-induced congenital malformations.
  • To identify potential therapeutic targets for intervention during diabetic pregnancies.

Main Methods:

  • Review of clinical and basic research studies on diabetes and congenital malformations.
  • Analysis of emerging research on genetic predisposition and molecular targets.

Main Results:

  • Evidence suggests early gestational induction of malformations in diabetic pregnancies.
  • The teratogenic process is multifactorial, involving genetic and environmental factors.
  • Potential therapeutic targets include antioxidants, folic acid, and interventions related to identified genes.

Conclusions:

  • Maternal diabetes significantly increases the risk of congenital malformations.
  • Further research is needed to confirm the efficacy and optimal use of antioxidants and folic acid.
  • Identification of specific genes and pathways involved may lead to novel preventive strategies.

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