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Direct subunit-dependent multimodal 5-hydroxytryptamine3 receptor antagonism by methadone

Tarek Z Deeb1, Douglas Sharp, Tim G Hales

  • 1Department of Pharmacology and Physiology, The George Washington University, Washington, DC 20037, USA.

Molecular Pharmacology
|January 10, 2009
PubMed
Summary

Methadone acts as a 5-hydroxytryptamine (5-HT)(3) receptor antagonist, affecting both 5-HT(3A) and 5-HT(3AB) subtypes. Its inhibitory effects are subunit-dependent and influenced by voltage, with distinct actions between R- and S-methadone enantiomers.

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