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Related Concept Videos

Non-gated Ion Channels01:24

Non-gated Ion Channels

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Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism....
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Voltage-gated Ion Channels01:26

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Voltage-gated ion channels are transmembrane proteins that open and close in response to changes in the membrane potential. They are present on the membranes of all electrically excitable cells such as neurons, heart, and muscle cells.
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Ion Channels01:19

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The movement of ions like sodium, potassium, and calcium into and out of the cell is essential to maintain the electrochemical gradient in living cells. The ion channels—a class of membrane transport proteins—help maintain this ionic gradient for the smooth functioning of physiological activities such as maintaining cell size and volume, conducting nerve impulses, and gas and nutrient exchange.
Ion channels are specialized integral membrane proteins on the plasma membrane that allow...
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Ligand-gated Ion Channels01:19

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Ligand-gated ion channels are transmembrane proteins with a channel for ions to pass through and a binding site for a ligand. The channel opens only when a ligand attaches to the binding site.
Three Subfamilies of Ligand-gated Ion Channels
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Mechanically-gated Ion Channels01:12

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Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
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The Role of Ion Channels in Neuronal Computation01:19

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A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
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  3. The Concise Guide To Pharmacology 2025/26: Ion Channels.
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  3. The Concise Guide To Pharmacology 2025/26: Ion Channels.

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The Concise Guide to PHARMACOLOGY 2025/26: Ion channels.

Stephen P H Alexander1, Jörg Striessnig2, Alasdair J Gibb3

  • 1Division of Physiology, Pharmacology & Neuroscience, School of Life Sciences, University of Nottingham Medical School, Nottingham, NG7 2UH, UK.

British Journal of Pharmacology
|December 29, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

The Concise Guide to Pharmacology 2025/26 offers a comprehensive overview of drug targets and their interactions. This biennial publication provides expert-curated recommendations for pharmacological tools, serving as a stable, citable record of drug target information.

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Area of Science:

  • Pharmacology
  • Drug Discovery
  • Biomedical Sciences

Background:

  • The British Journal of Pharmacology publishes biennial editions of the Concise Guide to Pharmacology.
  • The guide presents a comparative overview of drug target families and their pharmacology.
  • It is a condensed version of the comprehensive online database at www.guidetopharmacology.org.

Purpose of the Study:

  • To provide a clear, accessible, and well-structured summary of human drug targets and their interactions.
  • To offer expert-curated recommendations for selective pharmacological tools.
  • To serve as a permanent, citable, point-in-time record of pharmacological information.

Main Methods:

  • Summarization of key pharmacological properties for approximately 1900 human drug targets.
  • Inclusion of nearly 7000 interactions involving around 4400 ligands.
  • Expert curation of 'Gold Standard' selective pharmacological tools.

    • Main Results:

    • The 2025/26 edition covers six major pharmacological target classes: ion channels, G protein-coupled receptors, nuclear hormone receptors, catalytic receptors, enzymes, and transporters.
    • It includes official International Union of Basic and Clinical Pharmacology (NC-IUPHAR) classification and nomenclature where applicable.
    • Provides concise summaries, information on pharmacological tools, key references, and further reading suggestions for each target family.

    Conclusions:

    • The Concise Guide to Pharmacology 2025/26 is a valuable resource for researchers and scientists in pharmacology and related fields.
    • It serves as an essential reference for understanding drug targets and selecting appropriate pharmacological tools.
    • The guide complements the online database by providing a stable, citable snapshot of current pharmacological knowledge.