Related Experiment Video
Updated: Jun 26, 2026
Evaluation of the Effectiveness of Longitudinal Incision for Endoscopic Submucosal Excavation of Gastric Subepithelial Lesions
Published on: April 28, 2026
Initial experience in Brazil with endoscopic submucosal dissection for early gastric cancer using insulation-tipped
Daniela Medeiros Milhomem Cardoso1, Paulo Moacir de Oliveira Campoli, Chizu Yokoi
1Endoscopic Unit, Department of Gastrointestinal Oncology, Araújo Jorge Cancer Hospital, Rua 239, No. 181, Setor Universitário, CEP, 74605-070 Goiânia, GO, Brazil.
Background:
Endoscopic resection is an adequate treatment for subgroups of patients with early gastric cancer. Endoscopic submucosal dissection (ESD) represents a recent advance and leads to good results when adequately indicated. There is great experience with this technique in Japan and it is gaining acceptance among Western endoscopists. We present the first gastric ESD series performed in Brazil.
Methods:
Patients with well-differentiated adenocarcinomas macroscopically classified as early cancer, less than 30 mm with no ulcer or scar, were included. ESD was performed with an insulated-tip knife and electrosurgical unit with endocut mode. Clinicopathological aspects and morbidity were evaluated. The study was approved by the local ethics committee and informed consent was obtained from all participant subjects.
Results:
From October 2005 to July 2007, 160 patients received surgical treatment for gastric cancer; 44 patients (27.5%) had early gastric cancer. In this latter group, 15 procedures (ESD) were performed in 12 patients. The mean size of the lesions was 16.8 mm. Almost half of the lesions were located in the proximal third of the stomach and the mean elapsed time for the procedure was 140 min. In 80% of the cases resection was en bloc and 80% of the resections were considered curative. We had three perforations, which were managed clinically, and no bleeding.
Conclusion:
When adequately indicated, ESD is a safe and feasible technique.
