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Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...

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Related Experiment Video

Updated: Jun 26, 2026

Isolation and Th17 Differentiation of Na&iuml;ve CD4 T Lymphocytes
12:59

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

IL-17 and Th17 Cells.

Thomas Korn1, Estelle Bettelli, Mohamed Oukka

  • 1Technical University Munich, Department of Neurology, 81675 Munich, Germany. korn@lrz.tum.de

Annual Review of Immunology
|January 10, 2009
PubMed
Summary

A newly discovered subset of T helper cells, Th17 cells, produce IL-17 and other cytokines. These cells play key roles in host defense and autoimmune disease pathogenesis.

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • T helper cells differentiate into subsets like Th1 and Th2.
  • A novel subset, Th17 cells, characterized by IL-17 production, has been identified.

Purpose of the Study:

  • To summarize current knowledge on Th17 cell differentiation and effector functions.
  • To highlight the factors and transcription factors involved in Th17 development.

Main Methods:

  • Literature review and synthesis of existing research on Th17 cells.

Main Results:

  • Th17 cells produce IL-17, IL-17F, and IL-22, mediating tissue reactions.
  • Key differentiation factors (TGF-beta, IL-6, IL-21) and growth factors (IL-23) have been identified.
  • Transcription factors STAT3, RORgammat, and RORalpha are crucial for Th17 development.

More Related Videos

In Vitro Differentiation of Naive CD4+ T Cells into Pathogenic Th17 Cells in Mouse
07:46

In Vitro Differentiation of Naive CD4+ T Cells into Pathogenic Th17 Cells in Mouse

Published on: October 25, 2024

Detection and Isolation of Viable Mouse IL-17-Secreting T Cells
12:38

Detection and Isolation of Viable Mouse IL-17-Secreting T Cells

Published on: December 18, 2008

Related Experiment Videos

Last Updated: Jun 26, 2026

Isolation and Th17 Differentiation of Na&iuml;ve CD4 T Lymphocytes
12:59

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

In Vitro Differentiation of Naive CD4+ T Cells into Pathogenic Th17 Cells in Mouse
07:46

In Vitro Differentiation of Naive CD4+ T Cells into Pathogenic Th17 Cells in Mouse

Published on: October 25, 2024

Detection and Isolation of Viable Mouse IL-17-Secreting T Cells
12:38

Detection and Isolation of Viable Mouse IL-17-Secreting T Cells

Published on: December 18, 2008

Conclusions:

  • Th17 cell differentiation is linked to regulatory T cells (Tregs) due to TGF-beta involvement.
  • Understanding Th17 cells provides new insights into T cell differentiation, host defense, and autoimmune diseases.