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Related Concept Videos

Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
Therapeutic Drug Monitoring: Affecting Factors01:29

Therapeutic Drug Monitoring: Affecting Factors

Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.

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Related Experiment Video

Updated: Jun 26, 2026

A Standardized Acupotomy Protocol For The Treatment of Tenosynovitis of Hand Flexor Tendons In Human Patients
07:05

A Standardized Acupotomy Protocol For The Treatment of Tenosynovitis of Hand Flexor Tendons In Human Patients

Published on: May 26, 2026

[Tuna: clinical retrospective study addressing mid-term outcomes].

N Benoist1, P Bigot, P Colombel

  • 1Service d'urologie, faculté de médecine d'Angers, CHU d'Angers, 4, rue Larrey, 49933 Angers cedex 09, France.

Progres En Urologie : Journal De L'Association Francaise D'Urologie Et De La Societe Francaise D'Urologie
|January 13, 2009
PubMed
Summary

Radiofrequency (Tuna) treatment for benign prostatic hyperplasia (BPH) showed significant symptom improvement with minimal morbidity. However, a high retreatment rate suggests further long-term studies are needed to define Tuna

Related Experiment Videos

Last Updated: Jun 26, 2026

A Standardized Acupotomy Protocol For The Treatment of Tenosynovitis of Hand Flexor Tendons In Human Patients
07:05

A Standardized Acupotomy Protocol For The Treatment of Tenosynovitis of Hand Flexor Tendons In Human Patients

Published on: May 26, 2026

Area of Science:

  • Urology
  • Minimally Invasive Surgery

Context:

  • Benign prostatic hyperplasia (BPH) affects a significant portion of the aging male population.
  • Medical treatment failure necessitates alternative therapeutic options for symptomatic BPH.
  • Radiofrequency (Tuna) ablation presents a minimally invasive surgical approach.

Purpose:

  • To evaluate the efficacy and safety of radiofrequency (Tuna) ablation for treating symptomatic benign prostatic hyperplasia (BPH) in patients who have not responded to medical management.
  • To assess the impact of Tuna on lower urinary tract symptoms (LUTS) and quality of life.
  • To determine the morbidity associated with the Tuna procedure.

Summary:

  • A retrospective analysis of 28 patients treated with Tuna for BPH after medical treatment failure was conducted.
  • Significant improvements were observed in International Prostatic Symptoms Score (IPSS), urinary peak flow (Qmax), post-void residual urine (PVR), and quality of life at a mean follow-up of 20 months.
  • The procedure demonstrated minimal morbidity, although the retreatment rate was 46.4%.

Impact:

  • Tuna offers a viable treatment option for symptomatic BPH with favorable short-to-midterm outcomes.
  • The low morbidity profile makes Tuna an attractive alternative for select patient populations.
  • Further long-term studies are warranted to establish the definitive role of Tuna in the surgical management of BPH and to address the observed retreatment rates.