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Published on: January 12, 2020
Angiotensin-converting enzyme (ACE) and ACE2 levels in the cerebrospinal fluid of patients with multiple sclerosis
1Department of Geriatric Medicine, Graduate School of Medicine, Ehime University, Ehime, Japan. mz1965kawajj@khc.biglobe.ne.jp
Background:
We reported a reduction in the levels of angiotensin II in cerebrospinal fluid (CSF) from patients with multiple sclerosis (MS).
Objective And Methods:
To clarify the mechanism underlying this reduction, we assayed angiotensin-converting enzyme (ACE) and ACE2 concentrations along with angiotensin II concentrations in CSF samples from 20 patients with MS and 17 controls with non-neurological diseases.
Results:
ACE levels were significantly elevated in patients with MS compared with controls (48.42 +/- 4.84 vs 44.71 +/- 3.9 pg/mL), whereas ACE2 levels were significantly reduced (2.56 +/- 0.26 vs 2.78 +/- 0.24 pg/mL), acting toward a normalization of angiotensin II levels.
Conclusion:
These results further indicate an alteration of the intrathecal renin-angiotensin system in patients with MS.
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