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Published on: April 18, 2019

Inducible clindamycin resistance among clinical isolates of Staphylococci

A M Ciraj1, P Vinod, G Sreejith

  • 1Department of Microbiology, Melaka Manipal Medical College, Manipal University, Manipal, Karnataka 576 104, India. cirajam@yahoo.com

Indian Journal of Pathology & Microbiology
|January 13, 2009
PubMed
Abstract

Insights

A significant 13.1% of staphylococci isolates exhibited inducible clindamycin resistance (MLSBi phenotype). This finding highlights the need for routine D-testing to guide effective clindamycin therapy in clinical settings.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Clinical Science

Background:

  • Clindamycin therapy failures are linked to resistance mechanisms against macrolide, lincosamide, and streptogramin antibiotics.
  • Detecting inducible clindamycin resistance in staphylococcal isolates is crucial for effective treatment.

Purpose of the Study:

  • To determine the prevalence of inducible clindamycin resistance among clinical staphylococcal isolates.
  • To assess the significance of inducible resistance in Staphylococcus aureus (MRSA and MSSA) and coagulase-negative staphylococci (CONS).

Main Methods:

  • The D-test, utilizing erythromycin and clindamycin discs, was employed as per CDC guidelines.
  • Susceptibility testing was performed on 244 clinical isolates of staphylococci.

Main Results:

  • Inducible clindamycin resistance (MLSBi phenotype) was detected in 32 (13.1%) of the staphylococcal isolates.
  • Among these resistant isolates, 10 were methicillin-resistant Staphylococcus aureus (MRSA), 16 were methicillin-sensitive Staphylococcus aureus (MSSA), and 6 were coagulase-negative staphylococci (CONS).

Conclusions:

  • The study underscores the importance of incorporating inducible clindamycin resistance testing into routine antibiotic susceptibility testing.
  • Implementing the D-test can aid clinicians in selecting appropriate antibiotic therapies and improving patient outcomes.

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