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Published on: February 7, 2018
Inflammatory responses and oxidative stress from metal fume exposure in automobile welders
Jiin-Chyuan John Luo1, Kuang-Hung Hsu, Wu-Shiun Shen
1Laboratory of Occupational Medicine, Chang Gung University, Taiwan, People's Republic of China. luo5485@giga.net.tw
Objectives:
: Welding operations expose to metal fume. We investigated the inflammatory responses and oxidative stress from metal fume exposure in an automobile plant.
Methods:
: We recruited 258 automobile workers and measured the urine zinc, copper, and nickel to determine the exposure level, and examined the white blood cells, and IL-6 as inflammatory responses to the metal fume exposure. We also examined the relationship between glutathione (GSH) and metals exposure.
Results:
: There were significant association between urine metals levels and welding hours. Zinc was significantly associated with blood white cells, interleukin-6, and GSH. Copper was significantly associated with GSH, but nickel was significantly inversely associated with GSH.
Conclusions:
: Automobile welders appear to have significant metals exposure. White blood cells and IL-6 might be involved in inflammatory process of zinc fume exposure with zinc and copper increasing GSH, but nickel depleting it.
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