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Published on: September 21, 2021
The synthesis and in vivo evaluation of 2',2'-difluoro KRN7000
Leo Leung1, Cyrille Tomassi, Katrien Van Beneden
1School of Chemistry, University of Southampton Highfield, Southampton SO17 1BJ, UK.
Chemmedchem
|January 13, 2009
Abstract:
The synthesis of 2',2'-difluoro KRN7000 is described. In vivo evaluation demonstrates that this fluorinated glycolipid induces CD1d-dependent TCR activation of NKT cells, with a bias towards Th2 cytokine production.
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