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Updated: Jun 26, 2026

In situ Subcellular Fractionation of Adherent and Non-adherent Mammalian Cells
09:20

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[Cell protein p16INK4a hyperexpression in epithelial malignancies induced by human papillomaviruses]

G M Volgareva, L E Zavalishina, Iu Iu Andreeva

    Arkhiv Patologii
    |January 14, 2009
    PubMed

    Insights

    The protein p16INK4a is crucial for diagnosing human papillomavirus (HPV)-induced cervical cancer. Its overexpression in HPV-positive cells aids in early detection and understanding HPV-related cancers.

    Area of Science:

    • Oncology
    • Molecular Biology
    • Virology

    Context:

    • The protein p16INK4a acts as a cyclin-dependent kinase inhibitor.
    • Its expression is altered in various cancers, particularly those associated with human papillomavirus (HPV).
    • In cervical cancer (CCU), HPV infection leads to p16INK4a hyperexpression.

    Purpose:

    • To review the mechanisms behind p16INK4a hyperexpression in HPV-induced cancers.
    • To highlight the diagnostic value of p16INK4a testing for early CCU detection.
    • To discuss current challenges in interpreting p16INK4a detection results.

    Summary:

    • p16INK4a, a cyclin-dependent kinase inhibitor, is frequently absent in non-HPV-associated tumors but overexpressed in HPV-induced cervical cancer.
    • This hyperexpression at the mRNA and protein levels makes p16INK4a a valuable biomarker for early CCU diagnosis.
    • The review examines the molecular mechanisms driving this overexpression and the diagnostic utility of p16INK4a detection.

    Impact:

    • Provides evidence for the diagnostic value of p16INK4a in identifying HPV-related cancers.
    • Contributes to understanding the role of HPV in oncogenesis.
    • Addresses ambiguities in interpreting p16INK4a immunohisto-/cytochemical detection for clinical application.

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