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Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
Viruses and thyroiditis: an update.
Rachel Desailloud1, Didier Hober
1Laboratoire de Virologie/UPRES EA3610 Faculté de Médecine, Université Lille 2, CHRU Lille, Centre de Biologie/Pathologie et Parc Eurasanté, 59037 Lille, France. desailloud.rachel@chu-amiens.fr
Virology Journal
|January 14, 2009
Summary
Viruses may play a role in thyroiditis, including subacute thyroiditis and autoimmune thyroid diseases. Direct evidence shows viral presence in thyroid tissue, but their causal link requires further investigation for new treatments.
Area of Science:
- Endocrinology
- Virology
- Immunology
Background:
- Viral infections are recognized as potential environmental triggers for thyroiditis.
- Subacute thyroiditis and autoimmune thyroid diseases are complex conditions with multifactorial causes.
Purpose of the Study:
- To review and analyze human data on the association between viral infections and thyroiditis.
- To evaluate the evidence linking specific viruses to different types of thyroiditis.
Main Methods:
- Comprehensive review of virological data, including epidemiological, serological, and direct evidence of thyroid tissue infection.
- Analysis of human data across various thyroiditis types: subacute thyroiditis, Graves' disease, and Hashimoto's thyroiditis.
Main Results:
- Direct evidence of viral presence (retroviruses, mumps, HTLV-1, HIV, SV40, enterovirus, rubella, HSV, EBV, parvovirus) in thyroid tissue is available for different thyroiditis forms.
- Epidemiological and serological data suggest associations but require cautious interpretation due to lack of direct causality proof.
Conclusions:
- While direct evidence supports viral presence in thyroid tissue, their definitive role in causing thyroid diseases remains uncertain.
- Further research is essential to elucidate the precise relationship between viruses and thyroid diseases, paving the way for novel therapeutic and preventive strategies.
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