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Updated: Jun 26, 2026

3D Planning and Printing of Patient Specific Implants for Reconstruction of Bony Defects
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Reconstructing mandibular defects using autologous tissue-engineered tooth and bone constructs.

Harutsugi Abukawa1, Weibo Zhang, Conan S Young

  • 1Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Harvard School of Dental Medicine, Boston, MA, USA.

Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons
|January 14, 2009
PubMed
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This study shows that tissue engineering can rebuild jaws and teeth simultaneously in pigs. This regenerative medicine approach offers a promising alternative to traditional reconstructive surgery.

Area of Science:

  • Regenerative medicine
  • Biomaterials science
  • Craniofacial surgery

Background:

  • Current jaw reconstruction methods often involve multiple surgeries.
  • Replacing both bone and teeth presents significant reconstructive challenges.
  • Autologous tissue reconstruction offers potential for improved outcomes.

Purpose of the Study:

  • To investigate simultaneous mandibular and tooth reconstruction.
  • To evaluate tissue-engineered constructs in a Yucatan minipig model.
  • To explore a novel approach for autologous reconstruction.

Main Methods:

  • Preparation of tooth and bone constructs using autologous tissues.
  • Implantation of constructs into Yucatan minipigs.
  • Evaluation of regenerated tissues using advanced imaging and histology at 12 and 20 weeks.

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A Postoperative Evaluation Guideline for Computer-Assisted Reconstruction of the Mandible
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Published on: January 28, 2020

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Published on: August 4, 2020

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Published on: January 28, 2020

Main Results:

  • Successful regeneration of organized tooth structures (dentin, enamel, pulp, periodontal ligament).
  • Coordinated bone regeneration observed around the tooth constructs.
  • Absence of dental tissue formation in implants lacking tooth-bud cells.

Conclusions:

  • Tissue engineering is feasible for simultaneous autologous tooth and mandible reconstruction.
  • This pilot study provides a foundation for clinical translation.
  • Further research can refine this technique for human application.