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Cerebral microbleeds are a risk factor for warfarin-related intracerebral hemorrhage

Seung-Hoon Lee1, Wi-Sun Ryu, Jae-Kyu Roh

  • 1Department of Neurology, Seoul National University Hospital, Jongno-Gu, Seoul, Republic of Korea.

Neurology
|January 14, 2009
PubMed
Abstract

Insights

Cerebral microbleeds significantly increase the risk of warfarin-related intracerebral hemorrhage (ICH). Identifying microbleeds is crucial for assessing bleeding risk in patients taking warfarin.

Area of Science:

  • Neurology
  • Vascular Medicine
  • Radiology

Background:

  • Cerebral microbleeds indicate bleeding-prone microangiopathy.
  • Microbleeds may predict incident intracerebral hemorrhage (ICH).

Purpose of the Study:

  • To investigate the association between microbleeds and warfarin-related ICH incidence.

Main Methods:

  • Compared 24 ICH patients on warfarin with 48 controls.
  • Analyzed demographic, vascular, laboratory, and radiologic findings, including microbleeds.

Main Results:

  • Microbleeds were more frequent (79.2% vs 22.9%) and numerous in the ICH group.
  • Microbleed presence strongly correlated with warfarin-related ICH (adjusted OR, 83.12).
  • Increased prothrombin time and microbleeds were independent predictors of warfarin-related ICH.

Conclusions:

  • Underlying microbleeds are independently associated with warfarin-related ICH.
  • Further research is needed on warfarin use in patients with microbleeds.

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