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Updated: Jun 26, 2026

Quantification of Atherosclerosis in Mice
Published on: June 12, 2019
Antiphospholipid antibodies from a patient with primary antiphospholipid syndrome enhance experimental
Arnon Adler1, Arnon Afek, Yair Levy
1Department of Cardiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Background:
A 35-year-old man with primary antiphospholipid syndrome and no risk factors for atherosclerosis presented with postinfarction angina.
Investigations:
Coronary angiography, intravascular ultrasonography, injection of apolipoprotein-E-knockout mice with patient's IgG.
Diagnosis:
Myocardial infarction caused by a newly occluded proximal left circumflex artery. The left anterior descending artery exhibited a recanalized thrombus throughout the vessel.
Management:
The patient was managed by intensive angicoagulation including aspirin, clopidogrel, and enoxaparin for 2 months. After follow-up coronary angiography, he was switched to warfarin with a target International Normalized Ratio of 3.5-4.0.
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