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Updated: Jun 26, 2026

MultiBac System-Based Purification and Biophysical Characterization of Human Myosin-7a
Published on: August 23, 2024
Biology of myospryn: what's known?
1Folkhälsan Institute of Genetics and Department of Medical Genetics, University of Helsinki, Helsinki, Finland. jaakko.sarparanta@helsinki.fi
Abstract:
Myospryn (CMYA5, cardiomyopathy-associated 5) is a muscle-specific member of the TRIM superfamily, discovered a few years ago. Properties and functions of the little-studied protein remain largely enigmatic, but identified interactions have suggested that myospryn is involved in two seemingly distinct processes, protein kinase A signalling and vesicular trafficking. Recent findings have implicated myospryn in Duchenne muscular dystrophy and cardiac disease, making it an exciting new player in the field of muscle biology and pathology.
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