[Hormonal dependency of Walker 256 carcinosarcoma growing in rats]

The particularities of Walker 256 carcinosarcoma growing were studied in rats depending on hormonal background. Rats of lines NISAG and Brattleboro were characterized by the increased and lowered level of endogenous corticosteroids, respectively, in contrast with rats WAG different dynamics of growing tumors. If rats NISAG are not distinguished from rats WAG on the growing tumors, then the tumor grows weakly in the rats of line Brattleboro, and it takes place during the first fortnight only but then begins a regression up to disappearance. Velocity of tumor increasing is slowed in rats of WAG line under adrenalectomy but this effect disappears after introduction of exogenous cortisol. Cortisol introduction does not correct atypical dynamics of tumors in rats Brattleboro.