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Updated: Jun 26, 2026

Diagnosis of Neoplasia in Barrett’s Esophagus using Vital-dye Enhanced Fluorescence Imaging
Published on: May 11, 2014
Transnasal esophagoscopy: white-light versus narrowband imaging
Timothy J O'Brien1, Kourosh Parham
1Division of Otolaryngology, Department of Surgery, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT 06030-6228, USA.
Narrowband imaging (NBI) enhances transnasal esophagoscopy (TNE) for diagnosing Barrett's esophagus in patients with laryngopharyngeal reflux (LPR). NBI improved detection rates, including dysplasia, in this otolaryngological study.
Area of Science:
- Otolaryngology
- Gastroenterology
- Medical Imaging
Background:
- Transnasal esophagoscopy (TNE) is increasingly used in otolaryngology.
- Discrepancies exist between endoscopic findings and biopsies for Barrett's esophagus in laryngopharyngeal reflux (LPR) patients.
Purpose of the Study:
- To evaluate if TNE with narrowband imaging (NBI) improves diagnostic yield for Barrett's esophagus.
- To assess NBI's sensitivity in detecting mucosal changes indicative of Barrett's esophagus.
Main Methods:
- Retrospective chart review of 111 LPR patients undergoing TNE.
- Comparison of white light endoscopy versus NBI-equipped endoscopy.
- Biopsies taken from the squamocolumnar junction when Barrett's esophagus was suspected.
Main Results:
- Biopsy-proven Barrett's esophagus found in 13.5% of patients.
- NBI detected Barrett's esophagus in 15.1% of cases, slightly higher than white light (12.1%).
- All three cases of dysplasia were identified using NBI.
Conclusions:
- Narrowband imaging (NBI) shows potential as a valuable tool to enhance TNE diagnostic sensitivity.
- NBI may improve the detection of Barrett's esophagus and dysplasia in LPR patients.
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