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Updated: Jun 26, 2026

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
Published on: April 9, 2014
Better adherence with once-daily antiretroviral regimens: a meta-analysis
Jean-Jacques Parienti1, David R Bangsberg, Renaud Verdon
1Department of Biostatistics and Clinical Research, Côte de Nacre University Hospital, Caen, France. parienti-jj@chu-caen.fr
Abstract:
Once-daily regimens of antiretroviral therapy are simpler than other regimens, but whether such regimens are associated with better adherence to treatment is controversial. We performed a meta-analysis of 11 randomized, controlled trials (total number of subjects, 3029), which revealed that the adherence rate was better with once-daily regimens (+2.9%; 95% confidence interval, 1.0%-4.8%; P < .003) than with twice-daily regimens. This modest effect was more pronounced at the time of treatment initiation and for regimens for which all medications were taken once per day.
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