Related Experiment Video
Updated: Jun 26, 2026
08:20
Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice
Published on: July 12, 2018
Small intestinal nonmeckelian diverticulosis
Konstantinos Makris1, Gregory G Tsiotos, Vania Stafyla
1Department of Surgery, Metropolitan Hospital, Athens, Greece.
Journal of Clinical Gastroenterology
|January 15, 2009
Summary
Nonmeckelian jejunoileal diverticula (JID) are rare but significant lesions. Diagnosis can be challenging, with laparotomy often being the gold standard for definitive diagnosis and individualized treatment based on symptoms.
Area of Science:
- Gastroenterology
- Surgical Pathology
Background:
- Nonmeckelian jejunoileal diverticula (JID) are uncommon but can lead to significant clinical issues.
- Despite advanced diagnostic tools, identifying JID remains challenging.
Purpose of the Study:
- To review the diagnostic modalities and management strategies for nonmeckelian jejunoileal diverticula.
- To highlight the complexities in diagnosing and treating JID, particularly in extensive cases.
Main Methods:
- Review of diagnostic methods including upper GI contrast series, enteroclysis, ultrasound, CT, endoscopy, and laparoscopy.
- Discussion of surgical considerations, emphasizing individualized treatment and the risk of short bowel syndrome.
Main Results:
- JID can be asymptomatic or present with diverse symptoms like pain, malabsorption, or acute complications (hemorrhage, perforation).
- Laparotomy is the gold standard for definitive diagnosis of both symptomatic and asymptomatic JID.
- Surgical intervention is typically reserved for symptomatic cases, with careful consideration of resection extent.
Conclusions:
- Accurate diagnosis of JID requires a combination of imaging techniques, with laparotomy as the definitive method.
- Individualized surgical management is crucial, especially in extensive JID, to prevent complications like short bowel syndrome.
Related Concept Videos
01:27Diverticular Disease of the Colon
Diverticular disease involves the formation of diverticula—small sac-like outpouchings of the colonic wall—and their complications. It most commonly affects the sigmoid colon due to higher intraluminal pressure and structural vulnerability. It results from structural weakness and increased pressure in the colon, producing pseudodiverticula that may remain silent or progress to inflammation and serious complications.Structure of DiverticulaIn diverticulosis, these outpouchings are...
01:23Renewal of Intestinal Stem Cells
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the goblet,...
01:26Inflammatory Bowel Disease I: Introduction
Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
01:27Histology of the Small Intestine
The small intestine exhibits a unique histological structure that significantly enhances its function in digestion and nutrient absorption. These structures include circular folds, villi, and various specialized cells that collectively facilitate the digestion of food.
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...
01:19Appendicitis
Appendicitis is an acute inflammatory condition of the vermiform appendix, most commonly caused by obstruction of its lumen. The appendix is a narrow, blind-ended pouch that extends from the cecum, making it particularly prone to obstruction. Causes include fecaliths, lymphoid hyperplasia (often after viral infections), parasites, tumors, or foreign bodies. This obstruction initiates a cascade of pathological changes.Luminal Obstruction and Early InflammationAfter obstruction, normal mucosal...
01:25Inflammatory Bowel Disease III: Crohn's Disease
Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...