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Protective effect of taurine on rats with experimental insulin-dependent diabetes mellitus
L K Gavrovskaya1, O V Ryzhova, A F Safonova
1S. V. Anichkov Department of Neuropharmacology, Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg, Russia. iem_gavr@mail.ru
Abstract:
Taurine had the hypoglycemic effect during experimental insulin-dependent diabetes mellitus and decreased the concentrations of glucose and fructosamine, and increased the contents of insulin, C-peptide, and glycogen in the liver. Studying the dynamics of structural changes in pancreatic tissue confirmed a positive effect of taurine on beta-cell function. The protective effect of taurine manifested in the absence of morphological signs for alloxan-induced diabetes: decrease in the number and size of pancreatic islets, change in their distribution, reduction of beta-cell count, and accumulation of homogeneous deposits in islets.