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Related Concept Videos

Immunocytochemistry and Immunohistochemistry01:22

Immunocytochemistry and Immunohistochemistry

Immunocytochemistry (ICC) and immunohistochemistry (IHC) are techniques that use antibodies to check for specific proteins or antigens in a sample. The technique was first published by Albert Coons in 1941 to detect the presence of pneumococcal antigen in tissue sections from mice infected with Pneumococcus. Immunocytochemistry helps localization of proteins or antigens in individual cells like blood cells, stem cells, etc., while immunohistochemistry does the same for tissue samples.
These...
Transcytosis of IgG01:15

Transcytosis of IgG

Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...

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Related Experiment Video

Updated: Jun 26, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

[Immunocytoma IgA. Case report].

Bebiana Conde1, Ana Fernandes, Manuel Cunha

  • 1Centro Hospitalar de Trás-os-Montes e Alto Douro Av. da Noruega 5000 Vila Real. bebianaconde@gmail.com

Revista Portuguesa De Pneumologia
|January 16, 2009
PubMed
Summary

Immunocytoma, a rare indolent B cell lymphoma, typically affects older adults. This case highlights a 52-year-old male with Stage IV IgA immunocytoma and recurrent infections, treated successfully with chemotherapy and rituximab.

Related Experiment Videos

Last Updated: Jun 26, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

Area of Science:

  • Hematology
  • Oncology
  • Immunology

Background:

  • Immunocytoma is a rare, slow-growing non-Hodgkin's B cell lymphoma, accounting for 1-3% of cases.
  • It primarily affects individuals over 50, often presenting with lymphadenopathy, splenomegaly, and hepatomegaly.
  • Pulmonary involvement and monoclonal immunoglobulin peaks (IgM or IgA) are characteristic, though less common.

Observation:

  • A 52-year-old male presented with recurrent respiratory infections.
  • Diagnostic work-up revealed Stage IV immunocytoma with IgA monoclonal peaks.
  • The patient experienced frequent respiratory infections, necessitating prophylactic treatment.

Findings:

  • Initial management included prophylactic human immunoglobulin for respiratory infections.
  • Progression of the indolent lymphoma prompted treatment with cyclophosphamide, vincristine, prednisone, and rituximab (CVP-R).
  • The CVP-R regimen achieved a partial response lasting over two years.

Implications:

  • This case underscores the importance of recognizing immunocytoma's varied presentations, including pulmonary involvement and recurrent infections.
  • Effective management involves addressing both the indolent lymphoma and its complications.
  • Combination chemotherapy with rituximab (CVP-R) demonstrates efficacy in achieving durable partial responses in advanced-stage immunocytoma.