[The effect of topical metoprolol on intraocular pressure]

A single dose of topical 2% metoprolol, a new beta adrenergic antagonist, induced a significant IOP reduction in 20 normal volunteers (40 eyes) and 20 patients (40 eyes) with primary open angle glaucoma. The IOP of the latter 40 eyes remained significantly below the pretreatment levels during 6 months of continued application of the drug b.i.d. No changes were noted in pupil size, blood pressure, or heart rate, indicating that metoprolol is an effective ocular hypotensive.