[The ocular hypotensive effect and side reactions of domestic clonidine eyedrops]

The single dose test was performed on 100 various cases of glaucoma, with prolonged use t.i.d. for 1 month in 30 cases, for 3 months in 50 cases, for 6 months in 30 cases, and for 1 year in 20 cases. The IOP was lowered by an average 20%, the effect being similar to that of timolol. Clonidine lowered the blood pressure by less than 10%, and the papillary perfusion index was increased rather than decreased. The discomforts, such as thirst, somnolence and dizziness were tolerable and diminished with continued use. The author recommends its wide application in treatment of glaucoma.