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Glioblastoma multiforme in children: experience at Hospital Infantil de Mexico Federico Gomez
Federico Sánchez-Herrera1, Eduardo Castro-Sierra, Luis Felipe Gordillo-Domínguez
1Department of Neurosurgery, Hospital Infantil de México Federico Gómez, 06720 Mexico, D.F., Mexico.
Insights
Pediatric glioblastoma multiforme (GBM) patients showed more complications when younger and better survival with larger resections. Accurate pediatric-specific histology is needed for GBM diagnosis.
Area of Science:
- Pediatric Oncology
- Neuro-oncology
- Clinical Research
Background:
- Glioblastoma multiforme (GBM) is a rare and aggressive brain tumor in children.
- Understanding the clinical evolution of pediatric GBM is crucial for improving patient outcomes.
Purpose of the Study:
- To evaluate the clinical evolution of pediatric patients diagnosed with glioblastoma multiforme (GBM).
- To identify factors influencing complications and survival rates in pediatric GBM cases.
Main Methods:
- Retrospective analysis of pediatric GBM patients treated between January and May 2007.
- Variables included age, tumor size, histopathology, resection degree, hospital stay, complications, and outcome.
- Statistical analysis employed Pearson's chi-squared test and logistic regression.
Main Results:
- Sixteen pediatric GBM cases were identified with a mean age of 8.8 years.
- Younger patients experienced a higher frequency of complications.
- Greater tumor resection correlated with longer survival rates.
- Intracranial hypertension was the primary presentation mode; tumor size did not impact outcome.
Conclusions:
- Clinical outcomes in pediatric GBM are influenced by patient age and extent of surgical resection.
- Current histological classifications may be insufficient for accurate pediatric GBM diagnosis.
- Development of pediatric-specific histological classifications is necessary.
Objective:
To evaluate clinical evolution of pediatric patients diagnosed with glioblastoma multiforme (GBM) at Hospital Infantil de México Federico Gómez.
Methods:
Cases of patients treated from January to May, 2007, were included in this study. Variables analyzed were: age, diagnosis, size of tumor, histopathological description, degree of resection, time of stay in hospital, complications and outcome using Pearson's chi-squared test and logistic regression.
Conclusion:
Sixteen patients were identified. Mean age of presentation was 8.8. An increased frequency of complications was observed in younger patients and longer survival rates in patients with greater resections; main mode of presentation was directly related to intracranial hypertension; size of tumor was not related to evolution or outcome. Modern histological classifications especially designed for children are deemed necessary to accurately diagnose GBM.
