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Respiratory function during infancy in survivors of the INNOVO trial

Ah-Fong Hoo1, Caroline S Beardsmore, Rosemary A Castle

  • 1Portex Anaesthesia, Intensive Therapy and Respiratory Medicine Unit, UCL Institute of Child Health, London, UK. a.hoo@ich.ucl.ac.uk

Pediatric Pulmonology
|January 17, 2009
PubMed

Insights

Inhaled nitric oxide (iNO) did not improve long-term lung function in infants with severe respiratory failure. Airway function remained reduced at one year, regardless of iNO treatment, indicating persistent effects of neonatal respiratory distress.

Area of Science:

  • Neonatal Medicine
  • Pediatric Pulmonology
  • Respiratory Physiology

Background:

  • Inhaled nitric oxide (iNO) has shown short-term benefits for hypoxemic infants, improving oxygenation and reducing ECMO needs.
  • However, the long-term impact of iNO on infant lung function following severe respiratory failure remains unclear.

Purpose of the Study:

  • To compare lung function at approximately one year of age in infants with severe respiratory failure, with and without iNO treatment.
  • To compare these outcomes to the lung function of healthy infants.

Main Methods:

  • Maximal expiratory flow at functional residual capacity (V'maxFRC) was measured in survivors of the INNOVO trial at ~1 year of age.
  • Results were expressed as Z-scores, adjusted for sex and body size, using data from healthy controls.

Main Results:

  • Reduced V'maxFRC Z-scores were observed in infants with prior respiratory failure, irrespective of iNO allocation (mean Z-scores: -2.0 for iNO, -2.6 for no iNO).
  • No significant difference in lung function was found between the iNO and no iNO groups.
  • Significant respiratory morbidity occurred in both groups during the first year of life.

Conclusions:

  • Severe respiratory failure at birth is associated with reduced airway function at one year of age.
  • The administration of iNO does not appear to alter this long-term outcome.
Abstract

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