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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Industrial insulin production uses genetically engineered E. coli expressing a proinsulin gene controlled by a tryptophan promoter and containing a methionine linker for later cleavage. The cells also carry ampicillin resistance for selective growth. Seed cultures are stored at −80 °C and production begins by thawing a small amount to inoculate starter cultures, which are progressively scaled to a 50,000-L bioreactor. In the bioreactor, E. coli grow in nutrient-rich media under sterile, tightly...
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A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...

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Updated: Jun 26, 2026

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid
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Published on: February 27, 2019

Advances in peptide pharmaceuticals.

Cynthia L Stevenson1

  • 1Independent Pharmaceuticals Consultant, 100 W. El Camino Real, Mountain View, CA 94040, USA. cynthialstevenson@gmail.com

Current Pharmaceutical Biotechnology
|January 20, 2009
PubMed
Summary
This summary is machine-generated.

Peptide pharmaceuticals utilize advanced delivery strategies for improved bioavailability and protease resistance. This review covers marketed peptides and emerging peptidomimetics for various diseases.

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Area of Science:

  • Pharmaceutical Sciences
  • Medicinal Chemistry
  • Drug Delivery

Background:

  • Peptide pharmaceuticals require sophisticated delivery strategies to overcome challenges like protease degradation and low bioavailability.
  • Significant advancements have led to peptide-based therapeutics for numerous conditions.

Purpose of the Study:

  • To review current drug delivery strategies for peptide pharmaceuticals.
  • To highlight marketed peptide drugs and novel peptidomimetic therapies in clinical trials.

Main Methods:

  • Review of structure-activity relationships in peptide analog design.
  • Analysis of novel formulation and delivery system development.
  • Survey of clinical trial data for peptidomimetic therapies.

Main Results:

  • Peptide drug delivery incorporates analog generation for enhanced stability and bioavailability.
  • Marketed peptides treat a wide array of diseases including diabetes, cancer, and cardiovascular conditions.
  • Peptidomimetics represent a promising area of development in clinical trials.

Conclusions:

  • Innovative drug delivery is crucial for the success of peptide pharmaceuticals.
  • The therapeutic landscape for peptide drugs is expanding, with peptidomimetics showing significant potential.