Related Experiment Video
Updated: Jun 26, 2026

Endothelin-1 Induced Middle Cerebral Artery Occlusion Model for Ischemic Stroke with Laser Doppler Flowmetry Guidance in Rat
Published on: February 16, 2013
Cerebrovascular endothelin receptor upregulation in cerebral ischemia
1Department of Medicine, Institute of Clinical Sciences, Lund University, 221 85 Lund, Sweden. lars.edvinsson@med.lu.se
Abstract:
Stroke is a serious neurological disease and the third leading cause of death in the western world. In roughly 15 % of the cases, the cause is due to an intracranial haemorrhage, and the remaining 85 % represent ischemic strokes. Ischemic stroke is caused by the occlusion of a cerebral artery either by an embolus or by local thrombosis. Several studies have shown an involvement of the endothelin system in ischemic stroke. This review aims to examine the alterations of vascular endothelin receptor expression in ischemic stroke. Furthermore, studies of the intracellular signalling pathways leading to the enhanced expression of vascular endothelin receptors show that both protein kinase C (PKC) and mitogen activating protein kinase (MAPK) play important roles. The results from this work provide new perspectives on the pathophysiology of ischemic stroke, and give a possible explanation to the beneficial effects of treatment with PKC and MAPK inhibitors to limit the infarct volume.
Related Concept Videos
Ischemic Stroke ll: Pathophysiology
Cerebral Edema ll: Pathophysiology
Ischemic Stroke l: Introduction
Regulation of Angiogenesis and Blood Supply
Transient Ischemic Attack l: Introduction

