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Systemic and Local Drug Delivery for Treating Diseases of the Central Nervous System in Rodent Models
Published on: August 16, 2010
CNS drug delivery systems: novel approaches
Shadab A Pathan1, Zeenat Iqbal, Syed M A Zaidi
1Department of Pharmaceutics, Faculty of Pharmacy, Hamdard University, New Delhi-110062, India.
Recent Patents on Drug Delivery & Formulation
|January 20, 2009
Summary
Drug delivery to the brain faces challenges due to the blood brain barrier (BBB). This review examines recent patents for central nervous system (CNS) drug delivery systems to overcome these obstacles.
Area of Science:
- Neuroscience
- Pharmacology
- Biotechnology
Background:
- The brain is protected by the blood brain barrier (BBB) and blood cerebrospinal fluid barrier (BCSFB).
- These barriers hinder drug delivery for central nervous system (CNS) diseases like brain tumors and neurodegenerative disorders.
- Low success rates in CNS therapeutics are often due to poor drug delivery across the BBB.
Purpose of the Study:
- To comprehensively review recent patents on drug delivery systems for the central nervous system (CNS).
- To highlight strategies for overcoming the blood brain barrier (BBB) limitations in CNS drug development.
Main Methods:
- Review of existing literature and patent databases.
- Categorization of drug delivery strategies into non-invasive and invasive methods.
- Analysis of specific patented drug delivery systems for CNS disorders.
Main Results:
- Non-invasive methods include drug manipulation, carrier-mediated delivery, and intranasal delivery.
- Invasive methods involve disrupting BBB integrity or direct intracranial administration.
- Numerous patents exist for various CNS drug delivery approaches, with specific examples cited.
Conclusions:
- Effective drug delivery across the BBB remains a significant challenge for treating CNS diseases.
- A wide array of patented strategies, both invasive and non-invasive, are being developed to improve CNS drug delivery.
- Further research and patent analysis are crucial for advancing CNS therapeutics.
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