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Plasma B-type natriuretic peptide as a marker of myocardial asynchrony

Katarzyna Ciuraszkiewicz1, Marianna Janion, Dariusz Dudek

  • 1Swietokrzyskie Centrum Kardiologii, Akademia Swietokrzyska, Kielce, Poland.

Cardiology
|January 20, 2009
PubMed

Insights

Plasma B-type natriuretic peptide (BNP) levels in heart attack patients with intraventricular conduction defects (IVCD) are influenced by left ventricular (LV) asynchrony, especially with preserved LV systolic function.

Area of Science:

  • Cardiology
  • Biomarkers
  • Echocardiography

Background:

  • Myocardial infarction (MI) can lead to intraventricular conduction defects (IVCD).
  • Myocardial asynchrony is a potential complication in post-MI patients with IVCD.
  • B-type natriuretic peptide (BNP) is a biomarker used in heart failure assessment.

Purpose of the Study:

  • To evaluate asynchrony parameters in post-MI patients with IVCD.
  • To define the relationship between plasma BNP levels and echocardiographic measures of asynchrony.

Main Methods:

  • 158 patients 6 months post-MI were studied (126 with IVCD, 32 without).
  • Plasma BNP levels were measured using an immunoenzymatic method.
  • Left ventricular (LV) function and asynchrony were assessed via echocardiography.

Main Results:

  • Patients with post-MI IVCD exhibited significantly higher interventricular asynchrony and BNP levels compared to those without IVCD.
  • In patients with preserved LV ejection fraction (EF) > or =50%, interventricular asynchrony and intraventricular delay significantly impacted BNP levels.
  • In patients with reduced LV EF <50%, BNP levels correlated with the magnitude of EF.

Conclusions:

  • Plasma BNP levels 6 months post-MI are influenced by LV asynchrony in addition to LV function.
  • BNP may serve as a marker of LV asynchrony in post-MI patients with IVCD and preserved LV systolic function.
Abstract

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