Related Experiment Video
Updated: Jun 26, 2026
09:39
Preparation of Peripheral Nerve Stimulation Electrodes for Chronic Implantation in Rats
Published on: July 14, 2020
Defining normal duration for afterdischarges with repetitive nerve stimulation: a pilot study
Cynthia L Bodkin1, Kathleen D Kennelly, Kevin B Boylan
1Department of Neurology, Mayo Clinic Jacksonville, Jacksonville, Florida 32224, USA. cindy_bodkin@yahoo.com
Summary
Afterdischarge durations in repetitive nerve stimulation are similar in peripheral neuropathy patients and healthy controls. These findings suggest caution when diagnosing hyperexcitable nerve syndromes based on afterdischarge duration alone.
Area of Science:
- Neurology
- Clinical Neurophysiology
Background:
- Afterdischarges (ADs) on repetitive nerve stimulation (RNS) may aid in diagnosing cramp fasciculation syndrome.
- Normal AD duration in healthy individuals and those with neuromuscular diseases remains undefined.
Purpose of the Study:
- To characterize the distribution of AD durations in normal controls and patients with peripheral neuropathy.
- To establish normative data for AD durations following tibial nerve RNS.
Main Methods:
- Pilot study involving 18 normal controls and 18 patients with peripheral neuropathy.
- Tibial nerve RNS performed at 2, 5, 10, and 20 Hz.
- Measurement and statistical analysis of AD durations.
Main Results:
- Seventy-fifth percentiles of AD durations at 2, 5, 10, and 20 Hz were 315, 688, 745, and 928 ms for controls.
- Seventy-fifth percentiles for peripheral neuropathy patients were 143, 31, 323, and 542 ms.
- AD durations were comparable between peripheral neuropathy patients and controls.
Conclusions:
- Normal AD durations can exceed 500 ms, even surpassing 1000 ms, in individuals without subjective cramps and those with peripheral neuropathy.
- Interpretation of ADs in RNS for diagnosing hyperexcitable nerve syndromes requires caution due to overlapping durations.
