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Related Concept Videos

Randomized Experiments01:13

Randomized Experiments

The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
Simple...
Blinding01:11

Blinding

Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.
Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...

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Related Experiment Video

Updated: Jun 26, 2026

Measuring Maxillary Posterior Tooth Movement: A Model Assessment using Palatal and Dental Superimposition
07:32

Measuring Maxillary Posterior Tooth Movement: A Model Assessment using Palatal and Dental Superimposition

Published on: February 23, 2024

Web-based randomised controlled trials in orthodontics.

Iacopo Cioffi1, Roberto Martina, Ambrosina Michelotti

  • 1Department of Orthodontics and Temporomandibular Disorders, University of Naples Federico II, Naples, Italy.

Evidence-Based Dentistry
|January 20, 2009
PubMed
Summary
This summary is machine-generated.

This study highlights the benefits of using websites to manage large-scale orthodontic randomized controlled trials (RCTs). Web-based platforms enhance data quality, streamline randomization, and accelerate evidence acquisition in orthodontics.

Related Experiment Videos

Last Updated: Jun 26, 2026

Measuring Maxillary Posterior Tooth Movement: A Model Assessment using Palatal and Dental Superimposition
07:32

Measuring Maxillary Posterior Tooth Movement: A Model Assessment using Palatal and Dental Superimposition

Published on: February 23, 2024

Area of Science:

  • Orthodontics
  • Clinical Research Methodology
  • Health Informatics

Background:

  • Randomized controlled trials (RCTs) are the gold standard for evaluating orthodontic treatment efficacy.
  • Multicenter RCTs enhance statistical power but pose significant organizational challenges.
  • Effective management of large-scale RCTs requires high accuracy, standardization, and extensive resources.

Purpose of the Study:

  • To describe the development and benefits of a website supporting a large-scale orthodontic RCT.
  • To explore how web-based platforms can improve the efficiency and quality of multicenter RCTs.
  • To assess the potential of web-based RCTs in advancing orthodontic research globally.

Main Methods:

  • Development of a dedicated website to support a large-scale orthodontic RCT evaluating a functional appliance.
  • Implementation of web-based tools to facilitate data collection, randomization, and trial monitoring.
  • Focus on standardization of data collection, training, and organizational processes.

Main Results:

  • The developed website demonstrated potential to improve data collection quality and simplify the randomization process.
  • Web-based support can expedite data collection and enhance trial monitoring capabilities.
  • Such platforms contribute to streamlining complex, large-scale clinical trials.

Conclusions:

  • Web-based platforms are valuable tools for managing large-scale orthodontic RCTs.
  • These technologies can significantly enhance the quality, efficiency, and global reach of orthodontic research.
  • Utilizing web-based RCTs accelerates the acquisition of robust scientific evidence in orthodontics.