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Updated: Jun 26, 2026

An R-Based Landscape Validation of a Competing Risk Model
Published on: September 16, 2022
Statistical inference of risk difference in K correlated 2 x 2 tables with structural zero
Shun-Fang Wang1, Nian-Sheng Tang, Bo Zhang
1Department of Statistics, Yunnan University, Kunming 650091, People's Republic of China.
Abstract:
K correlated 2 x 2 tables with structural zero are commonly encountered in infectious disease studies. A hypothesis test for risk difference is considered in K independent 2 x 2 tables with structural zero in this paper. Score statistic, likelihood ratio statistic and Wald-type statistic are proposed to test the hypothesis on the basis of stratified data and pooled data. Sample size formulae are derived for controlling a pre-specified power or a pre-determined confidence interval width. Our empirical results show that score statistic and likelihood ratio statistic behave better than Wald-type statistic in terms of type I error rate and coverage probability, sample sizes based on stratified test are smaller than those based on the pooled test in the same design. A real example is used to illustrate the proposed methodologies.
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